Extended-release morphine sulfate in treatment of severe acute and chronic pain

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Extended-release morphine sulfate in treatment of severe acute and chronic pain

Morphine is the archetypal opioid analgesic. Because it is a short-acting opioid, its use has been limited to the management of acute pain. The development of extended-release formulations have resulted in the increased utilization of morphine in chronic pain conditions. This review documents the history of morphine use in pain treatment, and describes the metabolism, pharmacodynamics, formulat...

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Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.

OBJECTIVE To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain. PATIENTS AND METHODS This phase 3 study had an enriched-enrollment, randomized-withdrawal, dou...

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EmbedaTM: morphine sulfate extended-release capsules with sequestered naltrexone, a novel opioid formulation for the treatment of chronic pain

Opioids have been known to have analgesic properties for thousands of years. The chronic use of opioids for the treatment of chronic noncancer pain has only lately seen increased medical practice [1] owing to a relative lack of efficacy data, until recently, from well-controlled studies. The efficacy of morphine, oxycodone and oxymorphone in extended-release dosage forms has been demonstrated i...

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Effectiveness and safety of morphine sulfate extended-release capsules in patients with chronic, moderate-to-severe pain in a primary care setting

BACKGROUND The purpose of this study was to determine the effectiveness and safety of morphine sulfate extended-release capsules among primary care patients with chronic, moderate-to-severe pain using a universal precautions approach that assessed and monitored risk for opioid misuse and abuse. METHODS This open-label, uncontrolled, multicenter, prospective study was conducted in primary care...

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Comparative Effect of Cinnamon Essential Oil, Diclofenac and Morphine on Acute and Chronic Pain in Mice

Backgrounds and Aims: Cinnamomum Zeylanicum is a medicinal herb used in Iranian traditional medicine as an analgesic spice, which its analgesic effect has been experimentally confirmed. Thus, this study was conducted to compare the antinociceptive effect of cinnamon essential oil (CEO) with those of Morphine and Diclofenac in mice. Materials and Methods: 80 male albino mice were selected and...

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ژورنال

عنوان ژورنال: Journal of Pain Research

سال: 2010

ISSN: 1178-7090

DOI: 10.2147/jpr.s6529